Some ultrastructural features of Yoshida ascites hepatoma.

Hematogenous metastasis of Yoshida ascites Hepatoma in the chick embryo liver: ultrastructural changes in tumor cells.

Submicroscopic structure of Yoshida ascites hepatoma.

The electron microscope study of u ascites hepatoma cells confirms their epithelial origin. Isolated cells may occur, but they are mostly gathered to form islets. Cell surfaces exhibit microvilli. Cells are interconnected by means of microvilli and of structures similar to the epithelial "terminal bars." The cells line spaces and canaliculi similar to bile canaliculi. The cytoplasm is poorly di...

Marked hyperlipidaemia in rats bearing the Yoshida AH-130 ascites hepatoma.

Malignant tumour burden is a pathological s ta te associated with a considerable demand for nutrients by the growing tumour [l]. Although a great deal of work has been carried out, there are contradictory results about the effects of tumour burden on lipid metabolism both in experimental animals and man. Lipid oxidation has been reported either increased [2], unchanged [3] or decreased [4]. In ...

Metabolic-independent volume changes and Mg++ binding in mitochondria isolated from AH-130 Yoshida ascites hepatoma.

The mitochondria isolated in isotonic sucrose from AH-130 Yoshida ascites hepatoma appear spontaneously swollen (11, 12). This spontaneous swelling may be in part responsible for the inability of tumor mitochondria to undergo extensive volume changes in hypotonie conditions or in conditions that induce large-amplitude, metabolic-dependent, or metabolic-independent swelling in normal liver mitoc...

Carcinostatic effect of aliphatic aldehydes and aldehyde dehydrogenase activity in Ehrlich carcinoma, Sarcoma 180, and Yoshida AH 130 hepatoma.

The antitumor activity of 2,3-dihydroxybutyraldehyde on Ehrlich carcinoma, Sarcoma 180, and Yoshida AH 130 hepatoma, as well as the aldehyde dehydrogenase activity in these tumors, was studied. 2,3-Dihydroxybutyraldehyde at nontoxic doses (500 mg/kg body weight i.p. daily for 7 days) slowed down the growth of solid and ascites tumors in mice. The treatment completely prevented the development o...